Literature summary extracted from

Kornasiewicz, O.; Debski, M.; Stepnowska, M.; Sza?as, A.; Bar-Andziak, E.; Krawczyk, M.
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study (2010), Arch. Immunol. Ther. Exp., 58, 77-80.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.21.99.4	propylthiouracil	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.21.99.4	L-thyroxine + AH2	Homo sapiens	-	3,5,3'-triiodo-L-thyronine + iodide + A + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.21.99.4	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.21.99.4	Sephadex LH20 gel filtration	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.21.99.4	liver	healthy liver tissue expresses a high level of type 1 iodothyronine deiodinase	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.21.99.4	L-thyroxine + AH2	-	Homo sapiens	3,5,3'-triiodo-L-thyronine + iodide + A + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.21.99.4	type 1 iodothyronine deiodinase	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.21.99.4	dithiothreitol	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
1.21.99.4	Homo sapiens	the enzymatic activity of type 1 iodothyronine deiodinase is low in liver hemangioma	down

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Release 2023.1 (January 2023)